| 1. Round | 13/08/2021 | Go Ahead Eagles | - | sc Heerenveen | 0:1 | ||||
| 2. Round | 22/08/2021 | Feyenoord | - | Go Ahead Eagles | 2:0 | ||||
| 3. Round | 28/08/2021 | Go Ahead Eagles | - | Sparta Rotterdam | 2:0 | ||||
| 10. Round | 24/10/2021 | Vitesse | - | Go Ahead Eagles | 1:2 | ||||
| 13. Round | 21/11/2021 | Go Ahead Eagles | - | FC Groningen | 0:1 |  |
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| 14. Round | 27/11/2021 | Willem II | - | Go Ahead Eagles | 0:1 | ||||
| 15. Round | 05/12/2021 | Go Ahead Eagles | - | FC Twente | 1:2 | ||||
| 16. Round | 11/12/2021 | FC Utrecht | - | Go Ahead Eagles | 0:0 | ||||
| 17. Round | 19/12/2021 | Go Ahead Eagles | - | NEC Nijmegen | 0:2 | ||||
| 19. Round | 15/01/2022 | Go Ahead Eagles | - | RKC Waalwijk | 0:2 | ||||
| 21. Round | 06/02/2022 | FC Groningen | - | Go Ahead Eagles | 2:1 | ||||
| 26. Round | 12/03/2022 | Sparta Rotterdam | - | Go Ahead Eagles | 1:0 | ||||
| 27. Round | 19/03/2022 | Go Ahead Eagles | - | SC Cambuur | 3:0 | ||||
| 30. Round | 24/04/2022 | Fortuna Sittard | - | Go Ahead Eagles | 1:0 | ||||
| 31. Round | 01/05/2022 | Go Ahead Eagles | - | Vitesse | 1:2 | ||||
| 32. Round | 08/05/2022 | NEC Nijmegen | - | Go Ahead Eagles | 1:0 | ||||
| 33. Round | 11/05/2022 | Go Ahead Eagles | - | Feyenoord | 0:1 | ||||
| 34. Round | 15/05/2022 | sc Heerenveen | - | Go Ahead Eagles | 3:1 |  |
Zambia