| 2. Round | 09/05/2021 | Louisville City FC | - | Birmingham Legion | 1:1 | ||||
| 2. Round | 15/05/2021 | Birmingham Legion | - | Memphis 901 | 1:0 |  |
|||
| 3. Round | 17/06/2021 | Louisville City FC | - | Birmingham Legion | 2:0 | ||||
| 5. Round | 08/08/2021 | FC Tulsa | - | Birmingham Legion | 3:1 | |
|||
| 6. Round | 02/09/2021 | Sporting Kansas City 2 | - | Birmingham Legion | 0:1 | ||||
| 6. Round | 23/09/2021 | Atlanta United II | - | Birmingham Legion | 0:4 | ||||
| 7. Round | 02/10/2021 | Sporting Kansas City 2 | - | Birmingham Legion | 0:1 | ||||
| 7. Round | 10/10/2021 | Birmingham Legion | - | Indy Eleven | 3:1 |  |
|
||
| 7. Round | 24/10/2021 | Birmingham Legion | - | Sporting Kansas City 2 | 6:0 |
USA