| 1. Round | 23/07/2021 | FC Fredericia | - | Hobro IK | 2:0 | ||||
| 2. Round | 30/07/2021 | Hobro IK | - | Vendsyssel FF | 1:1 | ||||
| 3. Round | 08/08/2021 | HB Køge | - | Hobro IK | 1:1 | ||||
| 4. Round | 14/08/2021 | Hobro IK | - | Lyngby BK | 1:4 | ||||
| 5. Round | 18/08/2021 | Jammerbugt FC | - | Hobro IK | 1:1 | ||||
| 6. Round | 23/08/2021 | Hobro IK | - | Nykøbing FC | 1:2 | ||||
| 7. Round | 30/08/2021 | Hvidovre IF | - | Hobro IK | 2:2 | ||||
| 10. Round | 24/09/2021 | FC Helsingør | - | Hobro IK | 2:2 | ||||
| 11. Round | 01/10/2021 | Hobro IK | - | Fremad Amager | 5:0 | ||||
| 12. Round | 17/10/2021 | Lyngby BK | - | Hobro IK | 1:1 | ||||
| 13. Round | 22/10/2021 | Hobro IK | - | Jammerbugt FC | 0:1 | ||||
| 14. Round | 29/10/2021 | Hobro IK | - | Esbjerg fB | 2:6 | ||||
| 15. Round | 06/11/2021 | Nykøbing FC | - | Hobro IK | 3:1 | ||||
| 16. Round | 19/11/2021 | Hobro IK | - | Hvidovre IF | 2:1 | ||||
| 17. Round | 28/11/2021 | AC Horsens | - | Hobro IK | 2:1 | ||||
| 18. Round | 03/12/2021 | Hobro IK | - | FC Helsingør | 1:2 |  |
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| 19. Round | 26/02/2022 | Vendsyssel FF | - | Hobro IK | 0:3 | ||||
| 20. Round | 04/03/2022 | Hobro IK | - | HB Køge | 1:0 | ||||
| 21. Round | 11/03/2022 | Hobro IK | - | FC Fredericia | 3:1 |  |
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| 22. Round | 18/03/2022 | Fremad Amager | - | Hobro IK | 1:1 |
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