| 8. Round | 13/08/2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 12. Round | 11/09/2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 3:1 | ||||
| 13. Round | 18/09/2022 | Atlético San Luis [] | - | Club León [] | 0:4 | ||||
| 14. Round | 24/09/2022 | UANL Tigres [] | - | Atlético San Luis [] | 5:2 | ||||
| 16. Round | 08/10/2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 |
Mexico