| 1. Round | 25/07/2021 | Club Tijuana [U20] | - | UANL Tigres [U20] | 1:1 | ||||
| 4. Round | 13/08/2021 | FC Juárez [U20] | - | Club Tijuana [U20] | 1:3 | ||||
| 5. Round | 17/08/2021 | Club Tijuana [U20] | - | Puebla FC [U20] | 3:0 | ||||
| 7. Round | 27/08/2021 | Club Tijuana [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:0 |
Mexico