| 4. Round | 26/02/2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 6. Round | 14/03/2022 | The Strongest | - | Bolívar | 0:1 | ||||
| 7. Round | 03/04/2022 | CD Guabirá | - | The Strongest | 1:3 |  |
|||
| 8. Round | 11/04/2022 | Club Aurora | - | The Strongest | 1:0 | ||||
| 9. Round | 18/04/2022 | Oriente Petrolero | - | The Strongest | 1:1 | ||||
| 10. Round | 21/04/2022 | The Strongest | - | Atlético Palmaflor | 4:1 | ||||
| 11. Round | 24/04/2022 | Universitario de Sucre | - | The Strongest | 0:1 | ||||
| 13. Round | 08/05/2022 | Bolívar | - | The Strongest | 1:0 |  |
|||
| 14. Round | 12/05/2022 | Nacional Potosí | - | The Strongest | 1:1 | ||||
| 15. Round | 14/05/2022 | The Strongest | - | CD Guabirá | 0:0 | |
|||
| 16. Round | 21/05/2022 | The Strongest | - | Club Aurora | 1:0 | |
Bolivia