| 2. Round | 23/02/2022 | Plaza Colonia | - | The Strongest | 2:0 | ||||
| 2. Round | 02/03/2022 | The Strongest | - | Plaza Colonia | 3:0 | ||||
| 3. Round | 11/03/2022 | Universidad Catolica | - | The Strongest | 0:0 | ||||
| 3. Round | 18/03/2022 | The Strongest | - | Universidad Catolica | 2:1 | ||||
| Group B | 08/04/2022 | The Strongest | - | Libertad | 1:1 | ||||
| Group B | 14/04/2022 | Athletico Paranaense | - | The Strongest | 1:0 | ||||
| Group B | 28/04/2022 | The Strongest | - | Caracas FC | 1:1 |  |
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| Group B | 17/05/2022 | Caracas FC | - | The Strongest | 0:0 | ||||
| Group B | 26/05/2022 | Libertad | - | The Strongest | 4:1 |
Bolivia