| 1. Round | 05/06/2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 | ||||
| 11. Round | 09/06/2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 | ||||
| 22. Round | 02/08/2022 | Rangers | - | Santiago Wanderers | 1:2 | ||||
| 23. Round | 07/08/2022 | Santiago Wanderers | - | Fernández Vial | 2:2 | ||||
| 24. Round | 12/08/2022 | CD Magallanes | - | Santiago Wanderers | 0:1 |  |
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| 19. Round | 16/08/2022 | Santiago Wanderers | - | Deportes Temuco | 3:0 | ||||
| 25. Round | 21/08/2022 | Santiago Wanderers | - | Deportes Copiapó | 1:0 |  |
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| 26. Round | 28/08/2022 | Puerto Montt | - | Santiago Wanderers | 1:1 | ||||
| 27. Round | 06/09/2022 | Santiago Wanderers | - | Deportes Melipilla | 2:2 | ||||
| 28. Round | 10/09/2022 | Unión San Felipe | - | Santiago Wanderers | 2:3 | ||||
| 29. Round | 25/09/2022 | Santiago Wanderers | - | Recoleta | 0:0 | ||||
| 30. Round | 03/10/2022 | Barnechea | - | Santiago Wanderers | 1:0 | ||||
| 31. Round | 09/10/2022 | Santiago Wanderers | - | Cobreloa | 2:2 | ||||
| 34. Round | 02/11/2022 | Santiago Wanderers | - | Santa Cruz | 2:0 |
Chile