| 4. Round | 26/02/2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 5. Round | 05/03/2022 | The Strongest | - | Nacional Potosí | 1:1 | ||||
| 8. Round | 11/04/2022 | Club Aurora | - | The Strongest | 1:0 | ||||
| 11. Round | 24/04/2022 | Universitario de Sucre | - | The Strongest | 0:1 | ||||
| 15. Round | 14/05/2022 | The Strongest | - | CD Guabirá | 0:0 |  |
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| 16. Round | 21/05/2022 | The Strongest | - | Club Aurora | 1:0 |
Bolivia