| 1. Round | 03/07/2022 | Oriente Petrolero | - | The Strongest | 3:0 | ||||
| 3. Round | 10/07/2022 | Nacional Potosí | - | The Strongest | 1:5 | ||||
| 4. Round | 17/07/2022 | Universitario de Sucre | - | The Strongest | 0:3 | ||||
| 5. Round | 24/07/2022 | The Strongest | - | Club Aurora | 4:0 | ||||
| 6. Round | 28/07/2022 | The Strongest | - | Always Ready | 4:2 | ||||
| 2. Round | 04/08/2022 | The Strongest | - | Jorge Wilstermann | 2:0 |  |
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| 8. Round | 07/08/2022 | The Strongest | - | Universitario de Vinto | 3:2 | ||||
| 12. Round | 25/08/2022 | The Strongest | - | Blooming | 3:1 | ||||
| 14. Round | 30/08/2022 | The Strongest | - | CD Guabirá | 2:3 | ||||
| 16. Round | 09/09/2022 | The Strongest | - | Oriente Petrolero | 2:1 | |
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| 17. Round | 11/09/2022 | Jorge Wilstermann | - | The Strongest | 0:3 | ||||
| 18. Round | 17/09/2022 | The Strongest | - | Nacional Potosí | 1:1 | |
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| 19. Round | 02/10/2022 | The Strongest | - | Universitario de Sucre | 1:0 | |
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| 20. Round | 06/10/2022 | Club Aurora | - | The Strongest | 0:0 | ||||
| 22. Round | 13/10/2022 | The Strongest | - | Bolívar | 4:4 |  |
Colombia
Bolivia