| 1. Round | 05/08/2007 | VfL Bochum II | - | FC Schalke 04 II | 0:1 | ||||
| 13. Round | 21/10/2007 | FC Schalke 04 II | - | FC Gütersloh 2000 | 0:0 | ||||
| 16. Round | 11/11/2007 | SF Oestrich-Iserlohn | - | FC Schalke 04 II | 0:4 | ||||
| 18. Round | 02/12/2007 | FC Schalke 04 II | - | VfL Bochum II | 3:1 |  |
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| 19. Round | 09/12/2007 | Delbrücker SC | - | FC Schalke 04 II | 4:0 | ||||
| 20. Round | 17/02/2008 | FC Schalke 04 II | - | Rot Weiss Ahlen II | 1:0 | ||||
| 24. Round | 16/03/2008 | SV Lippstadt 08 | - | FC Schalke 04 II | 1:6 | ||||
| 27. Round | 06/04/2008 | FC Schalke 04 II | - | Sportfreunde Lotte | 0:2 | ||||
| 25. Round | 09/04/2008 | FC Schalke 04 II | - | Arminia Bielefeld II | 1:1 | ||||
| 31. Round | 04/05/2008 | FC Schalke 04 II | - | SV Schermbeck 1912 | 1:1 | ||||
| 32. Round | 18/05/2008 | Germania Gladbeck | - | FC Schalke 04 II | 1:1 | ||||
| 33. Round | 25/05/2008 | FC Schalke 04 II | - | SF Oestrich-Iserlohn | 1:1 | ||||
| 34. Round | 01/06/2008 | TSG Sprockhövel | - | FC Schalke 04 II | 1:2 |
Germany