| 2. Round | 01/08/2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
| 3. Round | 06/08/2021 | Zlaté Moravce | - | FK Senica | 1:1 | ||||
| 4. Round | 14/08/2021 | FK Senica | - | FC DAC 1904 | 1:1 |  |
|||
| 5. Round | 22/08/2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
| 9. Round | 25/09/2021 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 11. Round | 16/10/2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Round | 23/10/2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 15. Round | 20/11/2021 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 16. Round | 30/11/2021 | FK Senica | - | MŠK Žilina | 2:2 | ||||
| 17. Round | 04/12/2021 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 18. Round | 11/12/2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Round | 18/12/2021 | FK Senica | - | AS Trenčín | 1:0 | |
|||
| 20. Round | 12/02/2022 | Slovan Bratislava | - | FK Senica | 5:0 |
Slovakia