| 1. Round | 06/03/2022 | MŠK Žilina | - | Slovan Bratislava | 2:3 | ||||
| 3. Round | 19/03/2022 | MŠK Žilina | - | FC DAC 1904 | 2:2 |  |
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| 4. Round | 01/04/2022 | MŠK Žilina | - | MFK Ružomberok | 0:2 |  |
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| 6. Round | 16/04/2022 | FC DAC 1904 | - | MŠK Žilina | 2:0 | |
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| 8. Round | 04/05/2022 | MFK Ružomberok | - | MŠK Žilina | 3:0 | |
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Czech Republic