| 2. Round | 24/07/2022 | Spartak Trnava | - | Dukla Banská Bystrica | 1:2 |  |
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| 3. Round | 31/07/2022 | Spartak Trnava | - | FK Železiarne Podbrezová | 1:1 | ||||
| 4. Round | 07/08/2022 | Spartak Trnava | - | MŠK Žilina | 2:2 | |
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| 5. Round | 14/08/2022 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:4 |  |
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| 6. Round | 20/08/2022 | Spartak Trnava | - | FC DAC 1904 | 3:1 | ||||
| 8. Round | 31/08/2022 | Spartak Trnava | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 9. Round | 04/09/2022 | MFK Ružomberok | - | Spartak Trnava | 3:2 | ||||
| 10. Round | 11/09/2022 | AS Trenčín | - | Spartak Trnava | 0:2 | ||||
| 11. Round | 18/09/2022 | Spartak Trnava | - | Slovan Bratislava | 0:0 | |
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| 17. Round | 05/11/2022 | FC DAC 1904 | - | Spartak Trnava | 1:0 | ||||
| 16. Round | 24/11/2022 | Spartak Trnava | - | MFK Zemplín Michalovce | 4:1 | ||||
| 19. Round | 11/02/2023 | Tatran Liptovský Mikuláš | - | Spartak Trnava | 1:2 | ||||
| 20. Round | 17/02/2023 | Spartak Trnava | - | MFK Ružomberok | 0:2 | ||||
| 21. Round | 25/02/2023 | Spartak Trnava | - | AS Trenčín | 3:2 | |
Czech Republic