| 2. Round | 08/05/2021 | Nashville SC | - | New England Revolution | 2:0 | ||||
| 3. Round | 19/06/2021 | New York RB | - | Nashville SC | 2:0 | ||||
| 4. Round | 09/07/2021 | Nashville SC | - | Atlanta United FC | 2:2 |  |
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| 4. Round | 18/07/2021 | Nashville SC | - | Chicago Fire | 5:1 | ||||
| 4. Round | 22/07/2021 | Columbus Crew | - | Nashville SC | 0:0 | ||||
| 4. Round | 25/07/2021 | Nashville SC | - | FC Cincinnati | 3:0 | ||||
| 5. Round | 05/08/2021 | New England Revolution | - | Nashville SC | 0:0 | ||||
| 5. Round | 08/08/2021 | Inter Miami CF | - | Nashville SC | 2:1 | ||||
| 5. Round | 16/08/2021 | Nashville SC | - | D.C. United | 5:2 |
USA
Nigeria