| 2. Round | 05/03/2022 | San Jose Earthquakes | - | Columbus Crew | 3:3 |  |
|||
| 5. Round | 19/06/2022 | Columbus Crew | - | Charlotte FC | 1:1 | ||||
| 6. Round | 10/07/2022 | Chicago Fire | - | Columbus Crew | 2:3 | ||||
| 6. Round | 14/07/2022 | D.C. United | - | Columbus Crew | 2:2 | ||||
| 7. Round | 01/09/2022 | Columbus Crew | - | Inter Miami CF | 1:0 |
USA
Nigeria