| 1. Round | 18/07/2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 | ||||
| 2. Round | 24/07/2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 | ||||
| 3. Round | 28/07/2021 | Boca Juniors | - | San Lorenzo | 0:2 | ||||
| 6. Round | 16/08/2021 | Talleres de Córdoba | - | San Lorenzo | 2:0 | ||||
| 7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 8. Round | 26/08/2021 | Estudiantes | - | San Lorenzo | 2:0 | ||||
| 9. Round | 30/08/2021 | San Lorenzo | - | Patronato de Paraná | 3:0 | ||||
| 10. Round | 04/09/2021 | Platense | - | San Lorenzo | 1:1 | ||||
| 13. Round | 26/09/2021 | San Lorenzo | - | Defensa y Justicia | 2:1 | ||||
| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 23. Round | 30/11/2021 | San Lorenzo | - | Sarmiento de Junín | 1:0 |
Argentina