| 12. Round | 17/01/1981 | FC Groningen | - | FC Utrecht | 1:1 | ||||
| 18. Round | 30/01/1981 | MVV | - | FC Utrecht | 1:3 |  |
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| 19. Round | 07/02/1981 | FC Utrecht | - | FC Twente | 2:2 | ||||
| 20. Round | 14/02/1981 | FC Utrecht | - | Feyenoord | 2:0 | |
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| 21. Round | 27/02/1981 | Willem II | - | FC Utrecht | 0:1 | ||||
| 22. Round | 07/03/1981 | Sparta Rotterdam | - | FC Utrecht | 2:3 | ||||
| 23. Round | 14/03/1981 | FC Utrecht | - | Go Ahead Eagles | 1:1 | ||||
| 17. Round | 31/03/1981 | FC Utrecht | - | AFC Ajax | 1:2 | ||||
| 25. Round | 04/04/1981 | FC Utrecht | - | FC Wageningen | 5:0 | ||||
| 26. Round | 10/04/1981 | NAC Breda | - | FC Utrecht | 0:3 | ||||
| 27. Round | 19/04/1981 | FC Utrecht | - | PSV Eindhoven | 0:0 | ||||
| 28. Round | 25/04/1981 | SBV Excelsior | - | FC Utrecht | 2:2 | ||||
| 29. Round | 02/05/1981 | FC Utrecht | - | FC Groningen | 3:0 | ||||
| 30. Round | 08/05/1981 | FC Den Haag | - | FC Utrecht | 1:3 | ||||
| 31. Round | 16/05/1981 | FC Utrecht | - | AZ '67 Alkmaar | 2:2 | |
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| 32. Round | 22/05/1981 | PEC Zwolle | - | FC Utrecht | 0:3 | ||||
| 33. Round | 29/05/1981 | FC Utrecht | - | SC NEC | 0:1 | ||||
| 34. Round | 05/06/1981 | AFC Ajax | - | FC Utrecht | 1:0 |
Netherlands