| 9. Round | 19/10/1980 | Willem II | - | PSV Eindhoven | 1:6 | ||||
| 10. Round | 26/10/1980 | SBV Excelsior | - | Willem II | 0:2 |  |
|||
| 11. Round | 01/11/1980 | Willem II | - | FC Groningen | 4:1 | ||||
| 12. Round | 07/11/1980 | FC Den Haag | - | Willem II | 0:1 | ||||
| 19. Round | 07/02/1981 | Willem II | - | Feyenoord | 1:2 | ||||
| 20. Round | 14/02/1981 | Sparta Rotterdam | - | Willem II | 3:1 | ||||
| 21. Round | 27/02/1981 | Willem II | - | FC Utrecht | 0:1 | ||||
| 24. Round | 27/03/1981 | FC Wageningen | - | Willem II | 2:1 | ||||
| 25. Round | 04/04/1981 | Willem II | - | NAC Breda | 2:2 | ||||
| 26. Round | 10/04/1981 | PSV Eindhoven | - | Willem II | 4:0 | ||||
| 27. Round | 17/04/1981 | Willem II | - | SBV Excelsior | 2:1 | ||||
| 28. Round | 25/04/1981 | FC Groningen | - | Willem II | 0:2 | ||||
| 29. Round | 02/05/1981 | Willem II | - | FC Den Haag | 2:1 |  |
|||
| 30. Round | 08/05/1981 | AZ '67 Alkmaar | - | Willem II | 3:3 | ||||
| 31. Round | 16/05/1981 | Willem II | - | PEC Zwolle | 2:5 | ||||
| 32. Round | 22/05/1981 | SC NEC | - | Willem II | 4:0 | ||||
| 33. Round | 29/05/1981 | Willem II | - | AFC Ajax | 1:3 | ||||
| 34. Round | 05/06/1981 | MVV | - | Willem II | 2:2 |
Netherlands