| 1. Round | 22/08/1980 | Go Ahead Eagles | - | AFC Ajax | 2:4 | ||||
| 7. Round | 27/09/1980 | AFC Ajax | - | FC Groningen | 5:1 |  |
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| 9. Round | 18/10/1980 | AFC Ajax | - | AZ '67 Alkmaar | 1:2 | ||||
| 11. Round | 28/10/1980 | AFC Ajax | - | SC NEC | 2:0 | ||||
| 12. Round | 08/11/1980 | Sparta Rotterdam | - | AFC Ajax | 4:3 | ||||
| 13. Round | 21/11/1980 | MVV | - | AFC Ajax | 1:1 | ||||
| 14. Round | 29/11/1980 | AFC Ajax | - | FC Twente | 5:3 | ||||
| 15. Round | 06/12/1980 | Feyenoord | - | AFC Ajax | 4:2 | ||||
| 18. Round | 31/01/1981 | AFC Ajax | - | Go Ahead Eagles | 4:2 | ||||
| 19. Round | 07/02/1981 | Roda JC Kerkrade | - | AFC Ajax | 2:3 | ||||
| 20. Round | 13/02/1981 | FC Wageningen | - | AFC Ajax | 0:2 | ||||
| 22. Round | 06/03/1981 | PSV Eindhoven | - | AFC Ajax | 3:1 | ||||
| 24. Round | 28/03/1981 | FC Groningen | - | AFC Ajax | 0:1 | ||||
| 33. Round | 29/05/1981 | Willem II | - | AFC Ajax | 1:3 | ||||
| 34. Round | 05/06/1981 | AFC Ajax | - | FC Utrecht | 1:0 |
Netherlands