| 1. Round | 16/04/2022 | Manta FC [U19] | - | Atlético Santo Domingo [U19] | 0:1 |  |
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| 2. Round | 23/04/2022 | 9 de Octubre [U19] | - | Atlético Santo Domingo [U19] | 4:2 | |
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| 3. Round | 07/05/2022 | Atlético Santo Domingo [U19] | - | Delfín SC [U19] | 0:0 | ||||
| 4. Round | 14/05/2022 | Emelec [U19] | - | Atlético Santo Domingo [U19] | 3:0 | ||||
| 5. Round | 28/05/2022 | Atlético Santo Domingo [U19] | - | Guayaquil City [U19] | 0:1 | ||||
| 6. Round | 04/06/2022 | Atlético Santo Domingo [U19] | - | Manta FC [U19] | 3:1 | |
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| 7. Round | 10/07/2022 | Atlético Santo Domingo [U19] | - | 9 de Octubre [U19] | 3:0 | |
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| 8. Round | 15/07/2022 | Delfín SC [U19] | - | Atlético Santo Domingo [U19] | 1:0 | |
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| 10. Round | 05/08/2022 | Guayaquil City [U19] | - | Atlético Santo Domingo [U19] | 0:1 | |
Ecuador