| 1. Round | 29/07/2021 | TM Fútbol Club | - | Leones Negros | 3:2 | ||||
| 2. Round | 03/08/2021 | Club Celaya | - | TM Fútbol Club | 0:0 | ||||
| 3. Round | 11/08/2021 | TM Fútbol Club | - | Venados FC | 3:0 | ||||
| 6. Round | 31/08/2021 | Mineros de Zacatecas | - | TM Fútbol Club | 1:2 | ||||
| 11. Round | 10/10/2021 | TM Fútbol Club | - | Correcaminos UAT | 3:3 | ||||
| 17. Round | 17/11/2021 | TM Fútbol Club | - | Pumas Tabasco | 1:1 |
Mexico