1. Round | 08/08/2021 | Akademija Pandev | - | FC Struga | 1:1 | ||||
2. Round | 15/08/2021 | FC Struga | - | FK Pelister | 1:0 | ||||
3. Round | 18/08/2021 | FK Rabotnički | - | FC Struga | 0:0 | ||||
4. Round | 22/08/2021 | FC Struga | - | KF Shkupi | 4:2 | ||||
5. Round | 28/08/2021 | GFK Tikvesh | - | FC Struga | 1:1 | ||||
6. Round | 12/09/2021 | FC Struga | - | FK Skopje | 1:0 | ||||
7. Round | 19/09/2021 | FK Renova | - | FC Struga | 1:0 | ||||
8. Round | 26/09/2021 | FC Struga | - | KF Shkëndija 79 | 1:1 | ||||
9. Round | 02/10/2021 | FK Bregalnica Štip | - | FC Struga | 1:0 | ||||
10. Round | 16/10/2021 | FC Struga | - | FK Borec | 1:1 | ||||
11. Round | 24/10/2021 | Makedonija GP | - | FC Struga | 1:1 | ||||
12. Round | 30/10/2021 | FC Struga | - | Akademija Pandev | 0:0 | ||||
13. Round | 06/11/2021 | FK Pelister | - | FC Struga | 0:1 | ||||
14. Round | 21/11/2021 | FC Struga | - | FK Rabotnički | 1:0 |