| 2. Round | 14/04/2018 | Colorado Rapids | - | Toronto FC | 2:0 | ||||
| 2. Round | 21/04/2018 | Houston Dynamo | - | Toronto FC | 5:1 | ||||
| 2. Round | 28/04/2018 | Toronto FC | - | Chicago Fire | 2:2 |  |
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| 3. Round | 05/05/2018 | Toronto FC | - | Philadelphia Union | 3:0 | ||||
| 3. Round | 13/05/2018 | New England Revolution | - | Toronto FC | 3:2 | ||||
| 4. Round | 03/06/2018 | Columbus Crew | - | Toronto FC | 3:3 | |
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| 4. Round | 09/06/2018 | Philadelphia Union | - | Toronto FC | 0:2 | ||||
| 5. Round | 01/07/2018 | Toronto FC | - | New York RB | 0:1 | ||||
| 6. Round | 19/08/2018 | San Jose Earthquakes | - | Toronto FC | 1:1 | ||||
| 8. Round | 28/10/2018 | Toronto FC | - | Atlanta United FC | 4:1 |
USA