2. Round | 26/07/2021 | Cerro Porteño | - | Libertad | 1:1 | ||||
3. Round | 01/08/2021 | Libertad | - | Sol de América | 1:1 | ||||
4. Round | 07/08/2021 | Club Nacional | - | Libertad | 1:0 | ||||
5. Round | 16/08/2021 | Libertad | - | 12 de Octubre de Itauguá | 3:3 | ||||
6. Round | 24/08/2021 | Guaraní | - | Libertad | 2:2 | ||||
10. Round | 27/09/2021 | Guaireña FC | - | Libertad | 2:1 | ||||
12. Round | 17/10/2021 | Sol de América | - | Libertad | 0:4 | ||||
13. Round | 25/10/2021 | Libertad | - | Club Nacional | 1:2 | ||||
14. Round | 30/10/2021 | 12 de Octubre de Itauguá | - | Libertad | 0:1 |