| 1. Round | 25/08/2010 | Montevideo Wanderers | - | Nacional | 1:1 | ||||
| 3. Round | 05/09/2010 | Montevideo Wanderers | - | Tacuarembó | 2:0 | ||||
| 4. Round | 19/09/2010 | Defensor Sporting | - | Montevideo Wanderers | 1:2 |  |
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| 2. Round | 23/09/2010 | Peñarol | - | Montevideo Wanderers | 2:1 | |
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| 6. Round | 02/10/2010 | Racing | - | Montevideo Wanderers | 0:2 |  |
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| 7. Round | 10/10/2010 | Montevideo Wanderers | - | Danubio | 1:1 | ||||
| 8. Round | 17/10/2010 | El Tanque Sisley | - | Montevideo Wanderers | 1:1 | |
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| 9. Round | 23/10/2010 | Montevideo Wanderers | - | Fénix | 2:2 | ||||
| 10. Round | 30/10/2010 | Central Español | - | Montevideo Wanderers | 2:1 | ||||
| 11. Round | 07/11/2010 | Montevideo Wanderers | - | Bella Vista | 0:2 | ||||
| 12. Round | 13/11/2010 | CA Cerro | - | Montevideo Wanderers | 1:1 | ||||
| 13. Round | 21/11/2010 | Montevideo Wanderers | - | River Plate | 1:2 | |
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| 14. Round | 28/11/2010 | Liverpool | - | Montevideo Wanderers | 0:2 | ||||
| 15. Round | 04/12/2010 | Montevideo Wanderers | - | Miramar Misiones | 1:1 |
Uruguay