| 2. Round | 20/07/2018 | Rampla Juniors | - | Santa Fe | 0:0 | ||||
| 2. Round | 01/08/2018 | Santa Fe | - | Rampla Juniors | 2:0 | ||||
| Round of 16 | 19/09/2018 | Santa Fe | - | Millonarios | 0:0 | ||||
| Round of 16 | 03/10/2018 | Millonarios | - | Santa Fe | 3:5 pso | ||||
| Quarter-finals | 24/10/2018 | Santa Fe | - | Deportivo Cali | 1:1 | ||||
| Quarter-finals | 31/10/2018 | Deportivo Cali | - | Santa Fe | 1:2 | ||||
| Semi-finals | 09/11/2018 | Santa Fe | - | Atlético Junior | 0:2 |  |
Colombia