| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 | ||||
| 3. Round | 22/07/2022 | Deportivo Cali | - | Independiente Medellín | 2:2 | ||||
| 4. Round | 24/07/2022 | Independiente Medellín | - | Once Caldas | 1:1 | ||||
| 5. Round | 30/07/2022 | Cortuluá | - | Independiente Medellín | 1:0 |  |
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| 6. Round | 05/08/2022 | Independiente Medellín | - | La Equidad | 1:1 | ||||
| 7. Round | 14/08/2022 | Atlético Junior | - | Independiente Medellín | 4:2 | ||||
| 10. Round | 05/09/2022 | Independiente Medellín | - | Atlético Nacional | 4:3 | ||||
| 11. Round | 11/09/2022 | Independiente Medellín | - | América de Cali | 2:0 | ||||
| 13. Round | 23/09/2022 | Independiente Medellín | - | Deportivo Pereira | 2:1 |  |
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| 14. Round | 25/09/2022 | Envigado FC | - | Independiente Medellín | 1:2 | ||||
| 15. Round | 01/10/2022 | Independiente Medellín | - | Alianza Petrolera | 3:1 | ||||
| 12. Round | 27/10/2022 | Millonarios | - | Independiente Medellín | 1:2 | ||||
| 20. Round | 30/10/2022 | Deportivo Pasto | - | Independiente Medellín | 0:0 |
Uruguay