| 2. Round | 21/01/2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 3. Round | 31/01/2021 | Danubio | - | Peñarol | 0:1 |  |
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| 4. Round | 04/02/2021 | River Plate | - | Danubio | 0:4 |  |
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| 5. Round | 07/02/2021 | Danubio | - | Montevideo City Torque | 0:4 | |
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| 6. Round | 10/02/2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 8. Round | 18/02/2021 | Fénix | - | Danubio | 1:1 | |
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| 12. Round | 13/03/2021 | Danubio | - | Nacional | 2:1 | |
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| 13. Round | 19/03/2021 | Boston River | - | Danubio | 1:5 | |
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| 15. Round | 29/03/2021 | Rentistas | - | Danubio | 1:0 | |
Uruguay