| 1. Round | 18/04/2021 | New York RB | - | Sporting Kansas City | 1:2 | ||||
| 1. Round | 24/04/2021 | Sporting Kansas City | - | Orlando City | 1:1 | ||||
| 2. Round | 01/05/2021 | Real Salt Lake | - | Sporting Kansas City | 3:1 | ||||
| 2. Round | 10/05/2021 | Sporting Kansas City | - | Austin FC | 2:1 | ||||
| 2. Round | 13/05/2021 | Houston Dynamo | - | Sporting Kansas City | 1:0 | ||||
| 2. Round | 16/05/2021 | Sporting Kansas City | - | Vancouver Whitecaps | 3:0 | ||||
| 2. Round | 23/05/2021 | San Jose Earthquakes | - | Sporting Kansas City | 1:3 |  |
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| 3. Round | 12/06/2021 | Sporting Kansas City | - | Austin FC | 1:1 | ||||
| 3. Round | 20/06/2021 | Portland Timbers | - | Sporting Kansas City | 2:1 | |
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| 3. Round | 24/06/2021 | Sporting Kansas City | - | Colorado Rapids | 3:1 | ||||
| 3. Round | 26/06/2021 | Sporting Kansas City | - | Los Angeles FC | 2:1 | ||||
| 4. Round | 22/07/2021 | Sporting Kansas City | - | San Jose Earthquakes | 1:1 | |
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| 5. Round | 05/08/2021 | Los Angeles FC | - | Sporting Kansas City | 1:4 | ||||
| 5. Round | 08/08/2021 | Colorado Rapids | - | Sporting Kansas City | 0:0 | |
USA