| 2. Round | 02/05/2021 | FC Tulsa | - | Sporting Kansas City 2 | 2:0 | ||||
| 2. Round | 15/05/2021 | Sporting Kansas City 2 | - | Colorado Springs Switchbacks | 0:4 | ||||
| 2. Round | 20/05/2021 | Los Angeles Galaxy II | - | Sporting Kansas City 2 | 1:1 | ||||
| 2. Round | 23/05/2021 | Indy Eleven | - | Sporting Kansas City 2 | 2:0 | ||||
| 2. Round | 30/05/2021 | Sporting Kansas City 2 | - | El Paso Locomotive | 0:0 | ||||
| 3. Round | 10/06/2021 | Atlanta United II | - | Sporting Kansas City 2 | 2:2 | ||||
| 4. Round | 25/07/2021 | OKC Energy FC | - | Sporting Kansas City 2 | 0:0 | ||||
| 4. Round | 29/07/2021 | Sporting Kansas City 2 | - | Louisville City FC | 1:2 | ||||
| 5. Round | 08/08/2021 | Louisville City FC | - | Sporting Kansas City 2 | 4:1 | ||||
| 5. Round | 12/08/2021 | Birmingham Legion | - | Sporting Kansas City 2 | 4:2 | ||||
| 5. Round | 14/08/2021 | Sporting Kansas City 2 | - | Atlanta United II | 1:4 | ||||
| 5. Round | 22/08/2021 | Sporting Kansas City 2 | - | Indy Eleven | 1:1 | ||||
| 7. Round | 31/10/2021 | Oakland Roots | - | Sporting Kansas City 2 | 1:0 |
USA