| 2. Round | 28/02/2021 | 9 de Octubre | - | Mushuc Runa | 1:2 | ||||
| 3. Round | 06/03/2021 | Independiente del Valle | - | Mushuc Runa | 2:0 | ||||
| 4. Round | 14/03/2021 | Mushuc Runa | - | Manta | 4:2 | ||||
| 8. Round | 12/04/2021 | Orense SC | - | Mushuc Runa | 0:2 | ||||
| 9. Round | 17/04/2021 | Mushuc Runa | - | Barcelona | 2:2 | ||||
| 11. Round | 09/05/2021 | Mushuc Runa | - | Universidad Catolica | 2:6 | ||||
| 12. Round | 15/05/2021 | Deportivo Cuenca | - | Mushuc Runa | 1:2 | ||||
| 13. Round | 23/05/2021 | Mushuc Runa | - | Emelec | 1:2 |
Ecuador