| 1. Round | 19/02/2022 | Mushuc Runa | - | Universidad Catolica | 1:2 | ||||
| 3. Round | 05/03/2022 | Técnico Universitario | - | Mushuc Runa | 1:3 | ||||
| 4. Round | 12/03/2022 | Mushuc Runa | - | Cumbayá | 4:2 | ||||
| 6. Round | 03/04/2022 | Orense SC | - | Mushuc Runa | 0:0 | ||||
| 7. Round | 09/04/2022 | Mushuc Runa | - | Delfín SC | 1:2 |  |
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| 8. Round | 16/04/2022 | Gualaceo SC | - | Mushuc Runa | 3:2 | ||||
| 9. Round | 21/04/2022 | Mushuc Runa | - | Macará | 0:0 | ||||
| 10. Round | 24/04/2022 | LDU Quito | - | Mushuc Runa | 3:2 | ||||
| 11. Round | 30/04/2022 | Mushuc Runa | - | Guayaquil City | 2:0 | ||||
| 12. Round | 08/05/2022 | Emelec | - | Mushuc Runa | 4:0 | |
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| 13. Round | 14/05/2022 | Mushuc Runa | - | Aucas | 1:1 | ||||
| 14. Round | 23/05/2022 | Independiente del Valle | - | Mushuc Runa | 0:1 | ||||
| 15. Round | 28/05/2022 | Mushuc Runa | - | Deportivo Cuenca | 1:0 |
Ecuador