| 8. Round | 12/04/2022 | Unión San Felipe | - | San Luis | 2:0 | ||||
| 12. Round | 29/04/2022 | Unión San Felipe | - | Cobreloa | 1:1 | ||||
| 13. Round | 08/05/2022 | CD Magallanes | - | Unión San Felipe | 1:0 | ||||
| 1. Round | 06/06/2022 | Unión San Felipe | - | Recoleta | 0:0 | ||||
| 11. Round | 09/06/2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 | ||||
| 18. Round | 02/07/2022 | Recoleta | - | Unión San Felipe | 3:3 |  |
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| 19. Round | 08/07/2022 | Unión San Felipe | - | Deportes Copiapó | 3:1 | |
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| 20. Round | 18/07/2022 | Rangers | - | Unión San Felipe | 2:1 | |
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| 24. Round | 15/08/2022 | Unión San Felipe | - | Barnechea | 2:1 | |
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| 25. Round | 24/08/2022 | San Luis | - | Unión San Felipe | 2:2 | ||||
| 26. Round | 30/08/2022 | Unión San Felipe | - | Universidad de Concepción | 1:0 | ||||
| 27. Round | 07/09/2022 | Deportes Temuco | - | Unión San Felipe | 1:0 | |
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| 28. Round | 10/09/2022 | Unión San Felipe | - | Santiago Wanderers | 2:3 | |
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| 29. Round | 26/09/2022 | Cobreloa | - | Unión San Felipe | 1:0 | ||||
| 30. Round | 03/10/2022 | Unión San Felipe | - | CD Magallanes | 1:4 | ||||
| 31. Round | 11/10/2022 | Santa Cruz | - | Unión San Felipe | 4:0 | |
Chile