| 1. Round | 13/09/2020 | Heracles Almelo | - | ADO Den Haag | 2:0 | ||||
| 2. Round | 20/09/2020 | Willem II | - | Heracles Almelo | 4:0 | ||||
| 3. Round | 27/09/2020 | Heracles Almelo | - | PSV Eindhoven | 1:1 |  |
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| 4. Round | 03/10/2020 | Vitesse | - | Heracles Almelo | 3:0 | ||||
| 5. Round | 17/10/2020 | Heracles Almelo | - | RKC Waalwijk | 0:1 | ||||
| 6. Round | 25/10/2020 | Sparta Rotterdam | - | Heracles Almelo | 1:1 | ||||
| 7. Round | 01/11/2020 | Heracles Almelo | - | FC Utrecht | 4:1 | ||||
| 8. Round | 07/11/2020 | VVV-Venlo | - | Heracles Almelo | 3:2 | ||||
| 9. Round | 22/11/2020 | AFC Ajax | - | Heracles Almelo | 5:0 | ||||
| 16. Round | 12/01/2021 | Heracles Almelo | - | FC Emmen | 4:0 | ||||
| 19. Round | 26/01/2021 | PEC Zwolle | - | Heracles Almelo | 2:2 | ||||
| 21. Round | 05/02/2021 | Fortuna Sittard | - | Heracles Almelo | 0:1 | ||||
| 23. Round | 21/02/2021 | RKC Waalwijk | - | Heracles Almelo | 3:0 | ||||
| 34. Round | 16/05/2021 | AZ Alkmaar | - | Heracles Almelo | 5:0 |
Netherlands