| 2. Round | 13/01/2023 | Atlas Guadalajara | - | Mazatlán FC | 2:1 | ||||
| 3. Round | 21/01/2023 | Mazatlán FC | - | Santos Laguna | 1:2 | ||||
| 4. Round | 29/01/2023 | CF América | - | Mazatlán FC | 6:0 | ||||
| 5. Round | 04/02/2023 | Mazatlán FC | - | FC Juárez | 2:3 |  |
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| 6. Round | 11/02/2023 | Puebla FC | - | Mazatlán FC | 3:1 | |
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| 7. Round | 17/02/2023 | Mazatlán FC | - | CF Pachuca | 2:3 | ||||
| 8. Round | 19/02/2023 | Gallos Blancos | - | Mazatlán FC | 1:1 | ||||
| 9. Round | 25/02/2023 | Mazatlán FC | - | Pumas UNAM | 1:2 | ||||
| 10. Round | 04/03/2023 | Mazatlán FC | - | Cruz Azul | 3:1 | |
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| 11. Round | 12/03/2023 | Deportivo Toluca | - | Mazatlán FC | 4:1 | ||||
| 17. Round | 30/04/2023 | Deportivo Guadalajara | - | Mazatlán FC | 4:1 |
Ecuador