| 1. Round | 19/08/2000 | RBC Roosendaal | - | NEC Nijmegen | 2:3 |  |
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| 2. Round | 26/08/2000 | NEC Nijmegen | - | Vitesse | 4:1 | ||||
| 4. Round | 05/09/2000 | AFC Ajax | - | NEC Nijmegen | 0:0 | ||||
| 6. Round | 23/09/2000 | RKC Waalwijk | - | NEC Nijmegen | 0:0 | ||||
| 7. Round | 13/10/2000 | PSV Eindhoven | - | NEC Nijmegen | 0:0 | ||||
| 9. Round | 28/10/2000 | NEC Nijmegen | - | Willem II | 3:0 | ||||
| 18. Round | 19/12/2000 | Willem II | - | NEC Nijmegen | 2:0 | ||||
| 24. Round | 09/03/2001 | FC Twente | - | NEC Nijmegen | 1:1 | ||||
| 25. Round | 17/03/2001 | NEC Nijmegen | - | FC Groningen | 1:0 | ||||
| 26. Round | 31/03/2001 | NEC Nijmegen | - | AFC Ajax | 1:0 | ||||
| 27. Round | 06/04/2001 | sc Heerenveen | - | NEC Nijmegen | 5:0 | ||||
| 30. Round | 28/04/2001 | NEC Nijmegen | - | RKC Waalwijk | 5:1 | ||||
| 31. Round | 05/05/2001 | De Graafschap | - | NEC Nijmegen | 2:1 | ||||
| 33. Round | 19/05/2001 | Roda JC Kerkrade | - | NEC Nijmegen | 4:1 |
Netherlands