| 1. Round | 12/08/2015 | FC Groningen | - | FC Twente | 1:1 | ||||
| 2. Round | 15/08/2015 | FC Twente | - | ADO Den Haag | 1:4 | ||||
| 7. Round | 27/09/2015 | FC Twente | - | Roda JC Kerkrade | 2:1 | ||||
| 8. Round | 04/10/2015 | AZ Alkmaar | - | FC Twente | 3:1 | ||||
| 9. Round | 18/10/2015 | FC Twente | - | NEC Nijmegen | 1:0 | ||||
| 13. Round | 22/11/2015 | Feyenoord | - | FC Twente | 5:0 | ||||
| 14. Round | 28/11/2015 | FC Twente | - | Willem II | 1:3 |  |
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| 18. Round | 15/01/2016 | FC Twente | - | Heracles Almelo | 4:0 | ||||
| 21. Round | 31/01/2016 | FC Twente | - | FC Utrecht | 3:1 | ||||
| 27. Round | 12/03/2016 | FC Twente | - | PEC Zwolle | 2:1 | ||||
| 28. Round | 20/03/2016 | FC Twente | - | AZ Alkmaar | 2:2 |
Netherlands