| 1. Round | 05/05/2021 | Espuce FC [Women] | - | Ñañas [Women] | 0:1 | ||||
| 2. Round | 13/05/2021 | Quito FC [Women] | - | Espuce FC [Women] | 0:0 | ||||
| 3. Round | 16/05/2021 | Espuce FC [Women] | - | Sport JC [Women] | 1:0 | ||||
| 4. Round | 23/05/2021 | El Nacional [Women] | - | Espuce FC [Women] | 2:3 |  |
|||
| 5. Round | 29/05/2021 | Espuce FC [Women] | - | San Miguel [Women] | 3:2 | ||||
| 6. Round | 05/06/2021 | Espuce FC [Women] | - | Dragonas IDV [Women] | 0:2 | ||||
| 8. Round | 19/06/2021 | Ñañas [Women] | - | Espuce FC [Women] | 3:0 | ||||
| 9. Round | 26/06/2021 | Espuce FC [Women] | - | Quito FC [Women] | 1:1 | |
|||
| 10. Round | 04/07/2021 | Sport JC [Women] | - | Espuce FC [Women] | 0:1 | |
|||
| 7. Round | 07/07/2021 | LDU Quito [Women] | - | Espuce FC [Women] | 2:0 | ||||
| 11. Round | 11/07/2021 | Espuce FC [Women] | - | El Nacional [Women] | 3:2 | ||||
| 12. Round | 17/07/2021 | San Miguel [Women] | - | Espuce FC [Women] | 2:1 |  |
Ecuador