| 2. Round | 12/05/2021 | San Miguel [Women] | - | LDU Quito [Women] | 0:5 | ||||
| 5. Round | 29/05/2021 | Espuce FC [Women] | - | San Miguel [Women] | 3:2 | ||||
| 11. Round | 10/07/2021 | Ñañas [Women] | - | San Miguel [Women] | 2:1 | ||||
| 13. Round | 25/07/2021 | Quito FC [Women] | - | San Miguel [Women] | 3:1 |  |
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| 14. Round | 01/08/2021 | San Miguel [Women] | - | Dragonas IDV [Women] | 0:1 |
Ecuador