| 2. Round | 12/05/2021 | San Miguel [Women] | - | LDU Quito [Women] | 0:5 | ||||
| 3. Round | 19/05/2021 | El Nacional [Women] | - | San Miguel [Women] | 2:1 | ||||
| 4. Round | 23/05/2021 | San Miguel [Women] | - | Ñañas [Women] | 2:2 |  |
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| 5. Round | 29/05/2021 | Espuce FC [Women] | - | San Miguel [Women] | 3:2 |  |
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| 6. Round | 05/06/2021 | San Miguel [Women] | - | Quito FC [Women] | 3:2 | ||||
| 7. Round | 12/06/2021 | Dragonas IDV [Women] | - | San Miguel [Women] | 2:4 | ||||
| 8. Round | 19/06/2021 | San Miguel [Women] | - | Sport JC [Women] | 2:0 | ||||
| 9. Round | 26/06/2021 | LDU Quito [Women] | - | San Miguel [Women] | 5:0 | ||||
| 10. Round | 03/07/2021 | San Miguel [Women] | - | El Nacional [Women] | 1:0 | ||||
| 11. Round | 10/07/2021 | Ñañas [Women] | - | San Miguel [Women] | 2:1 | ||||
| 12. Round | 17/07/2021 | San Miguel [Women] | - | Espuce FC [Women] | 2:1 | ||||
| 13. Round | 25/07/2021 | Quito FC [Women] | - | San Miguel [Women] | 3:1 | ||||
| 14. Round | 01/08/2021 | San Miguel [Women] | - | Dragonas IDV [Women] | 0:1 |
Ecuador