1. Round | 08/01/2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 | ||||
3. Round | 22/01/2022 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
4. Round | 29/01/2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
6. Round | 12/02/2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
7. Round | 19/02/2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 | ||||
8. Round | 26/02/2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | ||||
9. Round | 05/03/2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
10. Round | 12/03/2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | ||||
11. Round | 19/03/2022 | CF Monterrey [] | - | Atlas Guadalajara [] | 1:1 | ||||
13. Round | 02/04/2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 | ||||
14. Round | 06/04/2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 | ||||
17. Round | 30/04/2022 | UANL Tigres [] | - | Atlas Guadalajara [] | 1:1 | ||||
18. Round | 07/05/2022 | Atlas Guadalajara [] | - | Atlético San Luis [] | 2:2 |