| 21. Round | 11/07/2021 | Atlético Santo Domingo | - | Independiente Juniors | 2:0 | ||||
| 22. Round | 14/07/2021 | Cumbayá | - | Atlético Santo Domingo | 3:1 |  |
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| 23. Round | 17/07/2021 | Atlético Santo Domingo | - | América de Quito | 0:2 | ||||
| 26. Round | 05/08/2021 | El Nacional | - | Atlético Santo Domingo | 3:2 | ||||
| 27. Round | 12/08/2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 |  |
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| 29. Round | 24/08/2021 | Independiente Juniors | - | Atlético Santo Domingo | 1:1 | |
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| 30. Round | 01/09/2021 | Atlético Santo Domingo | - | Cumbayá | 2:1 | ||||
| 31. Round | 08/09/2021 | América de Quito | - | Atlético Santo Domingo | 1:1 | ||||
| 32. Round | 15/09/2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:0 | ||||
| 34. Round | 29/09/2021 | Atlético Santo Domingo | - | El Nacional | 1:1 | ||||
| 35. Round | 06/10/2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 | ||||
| 36. Round | 13/10/2021 | Gualaceo SC | - | Atlético Santo Domingo | 1:0 |
Ecuador