| 1. Round | 27/08/2022 | Leones Negros II | - | Mineros de Fresnillo FC | 3:1 | ||||
| 2. Round | 03/09/2022 | Halcones de Zapopan | - | Leones Negros II | 1:1 |  |
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| 4. Round | 10/09/2022 | Los Cabos United | - | Leones Negros II | 1:0 |  |
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| 5. Round | 17/09/2022 | Chihuahua FC | - | Leones Negros II | 4:0 | ||||
| 6. Round | 24/09/2022 | Leones Negros II | - | Mexicali FC | 5:0 |  |
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| 7. Round | 28/09/2022 | Tecos Fútbol Club | - | Leones Negros II | 0:3 | |
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| 8. Round | 01/10/2022 | Leones Negros II | - | Tritones Vallarta | 0:3 | ||||
| 9. Round | 08/10/2022 | Coras de Nayarit | - | Leones Negros II | 1:2 | ||||
| 11. Round | 22/10/2022 | Tuzos de la UAZ | - | Leones Negros II | 2:0 |
Mexico