| 1. Round | 18/09/2021 | Escorpiones | - | Cafetaleros de Chiapas | 0:1 |  |
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| 2. Round | 24/09/2021 | CD Zap | - | Escorpiones | 2:1 | ||||
| 3. Round | 02/10/2021 | Escorpiones | - | Inter de Querétaro | 1:1 | ||||
| 7. Round | 23/10/2021 | Escorpiones | - | Yalmakan FC | 0:1 | ||||
| 8. Round | 31/10/2021 | Lobos ULMX | - | Escorpiones | 1:3 | ||||
| 9. Round | 06/11/2021 | Escorpiones | - | Reboceros de La Piedad | 1:4 | ||||
| 10. Round | 10/11/2021 | Deportivo Dongu | - | Escorpiones | 2:1 | ||||
| 11. Round | 13/11/2021 | Escorpiones | - | Cañoneros FC | 2:1 |
Guatemala
Mexico