| 1. Round | 20/09/2020 | Colima FC | - | Gavilanes de Matamoros | 2:0 | ||||
| 2. Round | 24/09/2020 | Tecos Fútbol Club | - | Colima FC | 1:1 | ||||
| 9. Round | 21/11/2020 | Colima FC | - | Saltillo FC | 3:0 | ||||
| 10. Round | 05/12/2020 | Colima FC | - | Reboceros de La Piedad | 0:3 | ||||
| 11. Round | 12/12/2020 | Leones Negros II | - | Colima FC | 0:2 | ||||
| 17. Round | 20/02/2021 | Colima FC | - | Mazorqueros | 3:0 |
Mexico