| 7. Round | 02/04/2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 |  |
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| 8. Round | 09/04/2022 | Atlético Palmaflor | - | Real Santa Cruz | 2:1 | ||||
| 10. Round | 21/04/2022 | CD Guabirá | - | Real Santa Cruz | 1:0 | |
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| 13. Round | 08/05/2022 | Always Ready | - | Real Santa Cruz | 5:0 | ||||
| 14. Round | 12/05/2022 | Club Aurora | - | Real Santa Cruz | 2:4 |
Bolivia