| 1. Round | 08/01/2021 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 4:1 | ||||
| 2. Round | 15/01/2021 | FC Juárez [U20] | - | Club Tijuana [U20] | 1:0 | ||||
| 4. Round | 30/01/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 6. Round | 12/02/2021 | Club Tijuana [U20] | - | Club León [U20] | 1:1 | ||||
| 7. Round | 21/02/2021 | UANL Tigres [U20] | - | Club Tijuana [U20] | 0:2 |  |
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| 8. Round | 28/02/2021 | CF Monterrey [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 9. Round | 03/03/2021 | Club Tijuana [U20] | - | CF América [U20] | 0:1 | ||||
| 10. Round | 08/03/2021 | CF Pachuca [U20] | - | Club Tijuana [U20] | 3:2 | ||||
| 11. Round | 13/03/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 3:1 |  |
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| 15. Round | 17/04/2021 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 16. Round | 23/04/2021 | Club Tijuana [U20] | - | Club Necaxa [U20] | 3:1 | ||||
| 17. Round | 01/05/2021 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 |
Mexico