| 2. Round | 22/01/2022 | Deportivo Dongu | - | Leviatán FC | 2:1 |  |
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| 5. Round | 12/02/2022 | Leviatán FC | - | Escorpiones | 1:5 | ||||
| 6. Round | 19/02/2022 | Cafetaleros de Chiapas | - | Leviatán FC | 4:0 | |
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| 3. Round | 23/02/2022 | Leviatán FC | - | Cañoneros FC | 0:3 | ||||
| 8. Round | 05/03/2022 | Inter de Querétaro | - | Leviatán FC | 2:2 |  |
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| 9. Round | 12/03/2022 | Leviatán FC | - | Montañeses FC | 0:4 |
USA
Mexico