| 1. Round | 20/08/2017 | Bor. Mönchengladbach | - | 1. FC Köln | 1:0 | ||||
| 2. Round | 25/08/2017 | 1. FC Köln | - | Hamburger SV | 1:3 | ||||
| 3. Round | 09/09/2017 | FC Augsburg | - | 1. FC Köln | 3:0 | ||||
| 4. Round | 17/09/2017 | Borussia Dortmund | - | 1. FC Köln | 5:0 |  |
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| 5. Round | 20/09/2017 | 1. FC Köln | - | Eintracht Frankfurt | 0:1 | ||||
| 6. Round | 24/09/2017 | Hannover 96 | - | 1. FC Köln | 0:0 | ||||
| 7. Round | 01/10/2017 | 1. FC Köln | - | RB Leipzig | 1:2 | ||||
| 12. Round | 18/11/2017 | 1. FSV Mainz 05 | - | 1. FC Köln | 1:0 | ||||
| 21. Round | 02/02/2018 | 1. FC Köln | - | Borussia Dortmund | 2:3 | ||||
| 22. Round | 10/02/2018 | Eintracht Frankfurt | - | 1. FC Köln | 4:2 | ||||
| 25. Round | 04/03/2018 | 1. FC Köln | - | VfB Stuttgart | 2:3 | ||||
| 26. Round | 12/03/2018 | Werder Bremen | - | 1. FC Köln | 3:1 | ||||
| 28. Round | 31/03/2018 | 1899 Hoffenheim | - | 1. FC Köln | 6:0 | ||||
| 29. Round | 07/04/2018 | 1. FC Köln | - | 1. FSV Mainz 05 | 1:1 | ||||
| 30. Round | 14/04/2018 | Hertha BSC | - | 1. FC Köln | 2:1 | ||||
| 31. Round | 22/04/2018 | 1. FC Köln | - | FC Schalke 04 | 2:2 | ||||
| 32. Round | 28/04/2018 | SC Freiburg | - | 1. FC Köln | 3:2 | ||||
| 33. Round | 05/05/2018 | 1. FC Köln | - | Bayern München | 1:3 |
Colombia